Pushing the Ultimate 

Limits of Biology

Why Does Medicine Need Microtechnology?

Sensing and manipulating biology at its ultimate “quantum” limits, by using single cells and single molecules, is poised to revolutionize medical diagnostics, transform our capabilities to develop drugs and cell therapies, and accelerate engineering of biological solutions to food and energy sustainability. Micro and nanotechnologies designed to operate at micrometer length scales are uniquely suited to sense and manipulate single cells and single molecules, allowing us to solve current problems in health and medicine.

Forcyte art - fullres2.jpg

How the Di Carlo Lab Plays a Role

The Di Carlo Lab leverages microfluidics, microfabrication, and nanotechnologies to develop interfaces with cells and molecules for applications in disease diagnosis, therapeutic discovery, tissue regeneration, and directed evolution. These tools not only excel at the manipulation and analysis of single cells and molecules, but also are cost-effective and easily accessible -- thus democratizing advanced biotechnology capabilities to solve medical problems.

Leveraging fluid momentum to control particles and fluids

Inertial Microfluidics 

Click to Learn More

Modular and micro-structured materials that seamlessly

integrate with tissues

Smart

Biomaterials

Click to Learn More

Mechano-

medicine

Measuring and manipulating mechanical properties of cells to diagnose and treat disease

Click to Learn More

Quantum Diagnostics

Diagnosing disease at the ultimate limit of single cells and
single molecules

Click to Learn More

Major Publications

Vortex

PNASFake.jpg

MAP Gels 

NatureMaterialsCover.jpg

FLECS

NatureBEFakeCover.jpg

109

Publications

15,119

Citations

32

Patents

5

Startups

180227_UCLA_2C1B1712.jpg

Startup Culture

CytovaleLogo.png
Vortex_Logo_RGB.png
ForcyteLogo5.png
TempLogo3.png
Ferrologix_Logo3.png

Meet the Professor

180227_UCLA_2C1B1808.jpg

Dr. Dino Di Carlo is a world-renowned UCLA professor, inventor, and serial entrepreneur who has made key innovations in biotechnology. He has co-founded 5 startup companies across diagnostic, medical device, and therapeutic industries.

Recently, he recognized a gap in the ability to widely deliver breakthrough therapeutics and diagnostics due to current specialized technologies requiring entirely new and costly infrastructure. To address this barrier, he is leveraging the ability to control fluids and chemistry precisely at the microscale level in order to develop low cost reagent platforms compatible with an installed base of instruments already present in laboratories around the world, thus placing all of the assay complexity into a self-contained smart "lab-on-a-particle."

linkedin.png
instagram.png

Notable Alumni

00100sPORTRAIT_00100_BURST20190426092201

Henry Tse

Chief Technology Officer

 Cytovale, Inc

"Dino is a dream PI. Purposeful science, patient when the experiments don't go as planned, and encouraging when the data takes you another direction."

Hamed photo.jpg
SCH_JHU.jpg

Hamed Amini

Group Lead

 Grail Inc

Soojung Claire Hur

Clare Booth Luce Assistant Professor

Johns Hopkins University

"Dino is a fantastic mentor who empowers his students to achieve their greatest potentials. He continuously guides them to unravel interesting and impactful scientific questions while providing enough freedom for creativity to spark. I witnessed that in the process each lab member would find their unique research style while accumulating great confidence in their abilities as a scientist."

"The mentorship from Dino and the team Di Carlo transformed me from an engineer focusing on how to make things work to an innovator remembering why we are trying to make things work."

Most Recent Paper

Science Advances (2020)

Wu CY, Ouyang M, Wang B, de Rutte J, Joo A, Jacobs M, Ha K, Bertozzi A, Di Carlo D

2020biorxivWU.jpg